The heparin manufacturer extracts glucosamine sulfate sodium from the intestinal mucosa of pigs or cattle, called heparin sodium.
Heparin sodium interferes with many parts of the blood clotting process and has anticoagulant effects both in vivo and in vitro. Its mechanism is complex, mainly through and antithrombin Ⅲ (AT - Ⅲ), and enhance the latter to activate Ⅱ, Ⅸ, X, Ⅺ and Ⅻ the inhibitory effect of clotting factors and its consequences involved in preventing platelet aggregation and destruction, inhibit the formation of blood coagulation activation of enzyme, blocking prothrombin into thrombin, inhibition of thrombin, thereby preventing fibrinogen to fibrin, Thus play an anticoagulant role.
Effects of heparin sodium and matters needing attention
Heparin is an anticoagulant that prolongs blood clotting in vivo and in vitro. Its anticoagulant action is quite chaotic and affects many aspects of the coagulation process. Its effect can be achieved through the following aspects:
(1) Block the composition and function of thrombin, so as to prevent the conversion of prothrombin into thrombin;
(2) Under the action of high concentration of modern antithrombin, the fibrinogen could not be directly transformed into fibrin cell protein;
(3) It can prevent platelet agglutination and injury.
1. Various hemorrhagic, delayed coagulation diseases, liver and kidney insufficiency, severe hypertension, cerebral hemorrhage, ulcer disease, pregnant women and postpartum should not be used.
2. Coagulation time should be measured regularly during medication.