At the present stage, heparin sodium is relatively scarce in the overseas market. As one of the largest heparin sodium API suppliers in China, Qingdao Jiulong Pharmaceutical Company, today we will talk about heparin sodium.
Sodium heparin is a sodium glucosamine sulfate salt, which is made up of molecules with different molecular weights. Disaccharide trisulphate is the main disaccharide unit of heparin. After complete hydrolysis, D-glucosamine, D-glucuronic acid, L-iduronic acid, acetic acid and sulfuric acid are produced.
It is a polymer of interacting derivatives of α-D-glucosaminoglucan (N-sulfated, O-sulfated, or N-acetylated) and uronic acid (α-L-iduluronic, β-D-glucuronic) bound by glycoside chains. Some of these components have properties that extend blood clotting time.
It is present in mammalian tissues and can be prepared from bovine lungs or from the mucous membranes of the small intestine of pigs, cattle, and sheep. The animal from which the extraction is made must meet the requirements for healthy animals suitable for human use, and all biological and procurement phases must be monitored by the quality management system. The process was verified by virus inactivation and the harmful contaminants could be removed.
Heparin sodium is a white or almost white powder with moisture absorption, easily soluble in water and optical rotation. It has characteristic absorption peak at 185-220nm and infrared characteristic absorption peak at 890cm-1,940cm-1. The absorption value of 1210-1150cm-1 can be used for rapid determination.