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What is the dilution and adverse effects of ulinastatin

  What is the dilution of ulinastatin and the adverse reactions. Ulinastatin is a serine protease inhibitor found in human blood and urine. Its anti-inflammatory mechanism includes inhibiting the effect of various inflammatory proteases, protecting endothelial cells, stabilizing vascular endothelium, improving microcirculation, and improving coagulation dysfunction. At the same time, it is also a non-specific protease inhibitor, protease inhibitor + membrane stabilizer + inflammatory factor regulator, which can be used clinically for the treatment of acute pancreatitis, chronic recurrent pancreatitis, and can also be used for the rescue of acute circulatory failure. So, what is the dilution of ulinastatin and what are the adverse reactions.

  According to the drug's instructions, ulinastatin is diluted with either 5% glucose injection or 0.9% normal saline, and the dosage can be increased or decreased according to age and symptoms.

  The adverse reaction of ulinastatin is

  1. The more common adverse reactions were granulocytopenia, diarrhea, reddening and pruritus of the skin, vascular pain, increased alanine aminotransferase and aspartate aminotransferase, etc.

  2. Occasional nausea, vomiting and diarrhea;

  3. Blood vessel pain, redness, itchy sensation, rash and so on;

  4. Occasionally see allergy, allergy should be stopped immediately, and appropriate treatment.

  In order to reduce the side effects of drugs, the following matters should be noted when using drugs: 1. Caution should be given to those with drug allergy history, food allergy or allergic constitution.

  2. When this product is used for acute circulatory failure, it should be noted that it cannot replace the general shock therapy (infusion, oxygen, surgical treatment, antibiotics, etc.), and the administration should be discontinued when the shock symptoms improve.

  3. Caution when using: Avoid using this product in combination with Gabeate or Gelobin. This product should be used immediately after dissolving.

  The plasma concentration of ulinastatin decreased rapidly after intravenous injection, which was mainly distributed in the kidney, liver and pancreas. It was eliminated from almost all tissues, with a biological half-life of about 24min and a half-life of about 40min. After 6h of administration, low molecular metabolites were excreted in urine, and excreted 24%. No accumulation was observed after continuous administration for 7 days.