Ulinastatin can reduce brain inflammation, improve blood-brain barrier permeability and brain tissue damage, regulate immune status, and reduce cognitive dysfunction. Ulinastatin has a neuroprotective effect on inflammation reduced the expression of TNF- and IL-6 mrna in rat models of acute pancreatitis and reduced brain injury. Ulinastatin has a neuroprotective effect on inflammation can significantly reduce brain tissue damage in the early stage of burns by lowering the expression levels of histone H3 and HSP70.
Differences in gene expression in brain tissue of sepsis rats and DNA microarray analysis showed that Ulinastatin had a protective effect on brain tissue by affecting gene expression of inflammatory factors. In five studies involving 461 postoperative elderly patients, use of Ulinastatin has a neuroprotective effect on inflammation in the early postoperative period (days 3 and 7) significantly reduced the incidence of cognitive impairment. In experimental autoimmune encephalomyelitis, Ulinastatin has a neuroprotective effect on inflammation was observed to protect against apoptotic oligos. Regulation of gene expression of inflammatory factors in brain tissue, protection of blood-brain barrier permeability and regulation of immune function are important mechanisms of Ulinastatin has a neuroprotective effect on inflammation neuroprotective effect during inflammation. The above results indicated that the neuroprotective effect of Ulinastatin has a neuroprotective effect on inflammation was mainly related to inhibiting inflammatory response, regulating immunity, anti-neuronal apoptosis, and protecting the blood-brain barrier. The major signaling pathways of Ulinastatin has a neuroprotective effect on inflammation in inhibiting inflammatory response and anti-neuronal apoptosis as well as the role and regulatory mechanism of UTI in glial cells, which are mainly involved in the inflammatory response of the nervous system, will be the focus of further research.