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The role of human menopausal gonadotropins

  Application of human menopausal gonadotropin

  Gonadotropin derived from animal hypophysis has been widely used in animal husbandry and aquaculture, but has no effect on human beings. HCG can be prepared from the urine of pregnant women, or a mixture of LH and FSH, referred to as human menopausal gonadotropin (HMG), can be used clinically for the treatment of hyposexual function.

  Mechanism of human menopausal gonadotropin secretion

  The production and release of pituitary gonadotropin is directly regulated by the hypothalamic luteinizing hormone-releasing hormone (LH-RH). LH and FSH target gland products - sex hormones in turn can affect the pituitary or hypothalamus secretion function. Therefore, THE secretion of LH-RH, LH and FSH and sex hormones restrict each other and fluctuates quite rhythmically. The repeated occurrence of the female menstrual cycle is the result of the fluctuations and rhythmic changes in the secretion of this tertiary hormone.

  Structure of human menopausal gonadotropins

  Gonadotropin (LH, FSH, HCG) and thyroid stimulating hormone (TSH) are composed of two peptide chains, and, which are combined by non-covalent bonds and contain glycosyl groups, the glycosyl parts of which are covalentially bound to individual asparagine, serine or threonine residues on the peptide chains. The two peptide chains can be split and recombined. LH, FSH, HCG and TSH have the same -peptide chain structure, while -peptide chain has its own characteristics, which determines the functional specificity of the above hormones.