Heparins Manufacturer describes how heparin affects the process of coagulation:
1. Inhibit the formation of part of thrombin into kinase: ① Heparin binds to antithrombin Ⅲ(AT-P) to form molecular heparin AT-P complex; ②AT-Ⅲ is a kind of serine as a protease tissue inhibitor, which can inactivate the blood clotting factors with a serine protease activity, such as factors JA, Eng A and Ing A. ③ Heparin is combined with the δ amino and lysine residues of AT-Ⅲ to form its complex, which can accelerate its inactivation of coagulation related factors, thus inhibiting the formation of prothrombin kinase in patients, and effectively counteracting the effect of prothrombin kinase formed.
2. Interfering with the role of thrombin detection: Small dose of heparin combined with the AT - Ⅲ even after the AT different parts - Ⅲ reaction (arginine residues) easier and direct the activity of thrombin research center (serine residues) combined into a stable thrombin - antithrombin complex formation, thus inactivated thrombin, inhibit plant fibrinogen levels into a kind of protein fiber cells.
3. Intervene the activation of thrombin on coagulation factor XⅢ, affect the formation of insoluble fibrin, and prevent the normal activation of thrombin on coagulation factor motility and metabolism.
4. Prevent platelet aggregation and destruction: Heparin prevents platelet adhesion and aggregation, thereby preventing platelet disintegration and releasing platelet factor 3 and serotonin. The anticoagulant effect of heparin is related to the strong negative charge of sulfate in heparin molecule. When the sulfate group is hydrolyzed or neutralized by protamine with strong positive charge, the anticoagulant activity is lost. Want to know about Heparin Sodium Price, welcome to consult!