Application of gonadotropin in menopause

     Gonadotropins (gonadotropins) produced from the pituitary gland of animals have been widely used in animal husbandry and aquaculture, but they are not effective for human beings. HCG can be made from the urine of pregnant women, or the mixed preparation of LH and FSH can be extracted from the urine of menopausal women, referred to as human menopausal gonadotropin (HMG), which can be used for the treatment of sexual dysfunction.

      The mechanism of gonadotropin secretion in human menopause

      The production and release of pituitary gonadotropin are directly regulated by luteinizing hormone releasing hormone (LH-RH) in the hypothalamus. Sex hormone, the target gland product of LH and FSH, can also affect the secretion function of pituitary gland or hypothalamus. Therefore, the secretion of lh-rh, LH and FSH as well as sex hormones restricts each other, and the fluctuation is quite rhythmic. The recurrence of the female menstrual cycle is the result of the fluctuation and rhythmic changes in the secretion of these three hormones.

     The structure of gonadotropin in human menopause

     Gonadotropin (LH, FSH, HCG) and thyroid stimulating hormone (TSH) are composed of two peptide chains, lubens and taprost, by means of non-covalent bond, and contain glycosyl groups. The glycosyl group is partially bound to individual asparagine, serine or threonine residues on the peptide chain through covalent bond. The two peptide chains can be separated and recombined. LH, FSH, and HCG share the same structure with TSH's lu-peptide chain, while the tae-peptide chain has its own characteristics, thus determining the functional specificity of the above-mentioned hormones.