Rational use of urokinase

　　1. The role

　　Urokinase is an enzymatic thrombolytic agent, which can directly act on the fibrinolysis system, promote the production of fibrinolytic enzyme, degrade fibrin clots, and have a good effect on newly formed thrombus. It can also inhibit adp-induced platelet aggregation and prevent thrombosis.

　　2.Effect of
 　　It is used to prevent thromboembolic diseases, such as acute myocardial infarction, acute extensive pulmonary embolism, acute cerebrovascular embolism, retinal artery or vein embolism, peripheral artery or vein embolism, etc.

　　3. Usage

　　Early onset intravenous medication.

　　4. Save

　　Lyophilized powder preparation should be stored at low temperature, the prepared solution should be used within 8 hours.

　　Adverse reactions to urokinase

　　Allergic to 1.

　　Urokinase antigenicity is small, less allergic reaction, a few patients may have fever, chills, headache, bronchial asthma, rash and other diseases.

　　2. Slight bleeding

　　Skin mucous membrane ecchymosis, hematuria, blood phlegm, a small amount of hemoptysis, hematemesis, hematoma at the injection site, etc.

　　3. Severe bleeding

　　Massive hemoptysis, gastrointestinal bleeding, retroperitoneal bleeding, intracranial/pericardial/spinal cord/mediastinal bleeding.

　　4. The digestive tract

　　Occasionally see nausea and vomiting, liver function is abnormal.

　　5. Reperfusion arrhythmia

　　Coronary thrombolytic therapy has a high incidence and requires ecg monitoring.