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Urokinase indications and adverse reactions

  This product is mainly used for thrombolytic treatment of thromboembolic diseases. These included acute extensive pulmonary embolism, coronary artery embolization and myocardial infarction within 6-12 hours of chest pain, acute stage cerebral vascular embolization with symptoms shorter than 3-6 hours, retinal artery embolization, and other severe peripheral arterial embolization of ilio-femoral vein thrombosis. It is also used to prevent thrombus formation after artificial heart flap operation, and to keep the vascular intubation and the thoracic cavity and pericardial cavity drainage tube unobtrusive. The therapeutic effect of thrombolytic therapy should be maintained by subsequent heparin anticoagulation.

  urokinase adverse reaction:

  1. When the dosage is large, a few patients may have bleeding phenomenon, mild bleeding such as skin, mucous membrane, naked eye and microscopic hematuria, blood sputum or a small amount of hemopsis, hematemesis, etc., take corresponding measures, symptoms can be relieved. In case of serious bleeding, such as a large number of haemoptysis or digestive tract hemorrhage, retroperitoneal bleeding, intracranial and spinal cord, mediastinal or pericardium hemorrhage, etc., should be suspended use, loss of blood to lose whole blood (it is better to blood, do not use the generation of plasma), can get effective control, consider using amino caproic acid in an emergency, aminomethylbenzoic acid against urokinase.

  2. Allergic reactions may occur in a few patients: the general manifestations are mild, such as bronchospasm, rash, etc. Anaphylactic shock is occasionally present. |

  3. Fever: about 2 ~ 3% of patients have fever of different degrees. Acetaminophen can be used as an antipyretic. Do not use aspirin or other antiplatelet antipyretics.

  4. Others: nausea, vomiting, loss of appetite, fatigue, and ALT elevation can be seen. Can cause haemorrhage, a few have allergic reaction, have a headache, disgusting, vomit, anorexia to wait to should stop medicine immediately.