Side effects are due to the low selectivity of the drug, the
pharmacological effects involve multiple organs and tissues, and when one effect
is used for treatment, other effects become side effects. Does reach heparin
sodium injection side effect big? Can it be eliminated?
Heparin sodium is an anti-blood suppository containing heparin sodium (low molecular weight heparin sodium). Da heparin sodium is a low molecular weight heparin sodium extracted from the intestinal mucosa of pigs with an average molecular weight of 5000. Daheparin sodium enhances its inhibition of clotting factor Xa and thrombin mainly through antithrombin (AT), so as to play its antithrombotic role. Heparin sodium enhanced the inhibition of coagulation factor Xa, compared with its ability to prolong plasma coagulation time (APTT). The effect of daheparin on platelet function and platelet adhesion was less than that of heparin, so it had only a small effect on hemostasis at the primary stage. Nevertheless, some of the antithrombotic properties of Heparin sodium are thought to be due to its effect on the vascular wall or fibrinolysis system.
Adverse reactions: especially in large doses, it may cause bleeding, and the common reported side effect is subcutaneous hematoma at the injection site. Rare thrombocytopenia, skin necrosis, allergic reactions and bleeding. Transient mild to moderate elevation of liver transaminase (AST, ALT) has been observed. Rarely seen in anaphylaxis.
Side effects are due to the low selectivity of the drug, and the pharmacological effects involve multiple organs and tissues. When one effect is used as the therapeutic target, other effects become side effects, which are predictable and generally unavoidable. Side effects are intrinsic to the drug, and vary with the purpose of medullary therapy, most of which are mild and disappear when the drug is discontinued.
Overrescue: Protamine inhibits the anticoagulation effect of heparin sodium. The prolongation of clotting time can be completely offset, but the anti-xa activity only cancels about 25-50%, and protamine per 1mg can inhibit the effect of 100IU of anti-xa da heparin sodium. Protamine itself has an inhibitory effect on hemostasis at the primary stage, so it can only be used in emergency situations