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Heparin sodium manufacturers to introduce heparin sodium encyclopedic knowledge

  First, heparin sodium crude products

  1. Heparin is a polysaccharide biochemical substance extracted from the mucosa of small intestine of pigs, which is called "heparin sodium" because it usually exists in the form of its sodium salt. Heparin has strong anticoagulant and antithrombotic functions, and is mainly used for anticoagulant and antithrombotic treatment in clinical practice. It is also a raw material for the production of medicines such as low molecular weight heparin.

  Drug category: anticoagulant drugs and thrombolytic drugs

  2. Properties: it is a colorless or light yellow clear liquid.

  3. Indications: for the prevention and treatment of thrombotic or embolic diseases (such as myocardial infarction, thrombophlebitis, pulmonary embolism, etc.); Diffuse intravascular coagulation (DIC) due to various causes; It is also used in hemodialysis, extracorporeal circulation, catheterization, microvascular surgery and other operations and anticoagulation treatment of some blood samples or instruments.

  4. Pharmacology and toxicology: Due to its physical and chemical properties with strong negative charge, this product can interfere with many links of the blood coagulation process, and has anticoagulant effect in vivo and in vitro. Its mechanism is complex, mainly through and antithrombin Ⅲ (AT - Ⅲ), and enhance the latter to activate Ⅱ, Ⅸ, Ⅹ, Ⅺ and Ⅻ inhibition of clotting factors. The results involve preventing platelet agglutination and destruction, and impeding the formation of thrombin-activating enzyme. Preventing prothrombin from becoming prothrombin; It inhibits thrombin, thereby preventing fibrinogen from becoming fibrin.

Heparin sodium manufacturers to introduce heparin sodium encyclopedic knowledge

  Two, heparin sodium boutique

  1. Drug category: anticoagulant drugs and thrombolytic drugs

  2. Properties: it is a colorless or light yellow clear liquid.

  3. Pharmacology and toxicology: Due to its physical and chemical properties with strong negative charge, this product can interfere with many links of the blood coagulation process, and has anticoagulant effect in vivo and in vitro. Its mechanism is complex, mainly through and antithrombin Ⅲ (AT - Ⅲ), and enhance the latter to activate Ⅱ, Ⅸ, Ⅹ, Ⅺ and Ⅻ inhibition of clotting factors. The results involve preventing platelet agglutination and destruction, and impeding the formation of thrombin-activating enzyme. Preventing prothrombin from becoming prothrombin; It inhibits thrombin, thereby preventing fibrinogen from becoming fibrin.

  4. Indications: for the prevention and treatment of thrombotic or embolic diseases (such as myocardial infarction, thrombophlebitis, pulmonary embolism, etc.); Diffuse intravascular coagulation (DIC) due to various causes; It is also used in hemodialysis, extracorporeal circulation, catheterization, microvascular surgery and other operations and anticoagulation treatment of some blood samples or instruments.

  3. Enoxaparin sodium

  Enoxaparin sodium alias: Xeroxaparin, enoxaparin

  Enoxaparin, LMW-H,Clexane

  Ingredient: Enoxaparin sodium

  1. Efficacy: Enoxheparin sodium can effectively prevent deep vein thrombosis and pulmonary embolism, effectively treat venous thrombosis, prevent thrombosis in extracorporeal blood during hemodialysis, and treat unstable angina pectoris and non-Q wave myocardial infarction.

  2. Dosage and administration: to prevent deep vein thrombosis, adults with high risk of thrombosis were given 40mg at 12 hr before surgery, followed by subcutaneous injection of 40mg every 24hr. Patients at moderate thrombotic risk were given 20mg at 2hr preoperatively, followed by subcutaneous injection every 24 hr. The course should last 10-14 days or until the risk of thrombosis has disappeared. Treatment of venous thrombosis at 1 mg/kg bw, subcutaneous administration every 12 hr for 10 days. Single dose before extracorporeal circulation dialysis: 1mg/kg body weight. The above dose is sufficient for a 4hr dialysis course (unless fibrin rings are formed), and a quarter of the above dose must be added per hour if the dialysis is prolonged. Unstable angina pectoris and non-q-wave myocardial infarction were subcutaneously administered at 1mg/kg body weight every 12 hr within 24hr, lasting for 6-8 days until clinical symptoms stabilized.

  3. Contraindications: acute bacterial endocarditis, massive hemorrhage, thrombocytopenia; Active digestive ulcer, stroke (except for systemic embolism) and bleeding tendency.

  4, adverse reactions: will lead to thrombocytopenia, abnormal liver function. Occasional changes of transaminase and alkaline phosphatase were observed.

  5. Precautions: This drug should not be used for intramuscular injection. Use with caution in patients with hepatic insufficiency, uncontrolled arterial hypertension, history of gastrointestinal ulcer, and pregnant women. Pregnant women should weigh the pros and cons of using this drug.

  6. Specifications: Injections are mainly divided into two doses of 20mg x. 40 mg x 2 pieces. 60mg x 2 pieces. 80mg x 2 pieces. 100mg x 2 pieces.

  4. Heparin

  1. Efficacy of heparin: effective prevention and treatment of thrombosis and embolism, such as pulmonary embolism, myocardial infarction, thrombophlebitis, postoperative thrombosis, etc. Heparin can effectively treat disseminated intravascular coagulation caused by various reasons, and early application can prevent the consumption of fibrin and coagulation factors. Other in vivo and in vitro anticoagulants, such as cardiac catheterization, cardiac surgery cardiopulmonary bypass, hemodialysis, etc.

  2. Quality standard: USP29 EP5 BP2005.

  3. Packing specification: 5kg per barrel, medical aluminum bottles, lined with two layers of plastic bags, carton packaging.

  V. Naltreheparin

  1. Efficacy of Naltreheparin: it is mainly used to prevent thromboembolic diseases, especially for high risk patients (respiratory failure, respiratory infection, heart failure) in general surgery and orthopedic surgery, and for thromboembolic diseases in critical condition monitoring patients; For the treatment of thromboembolic diseases and for the prevention of blood clots in hemodialysis.

  2. Quality standard: USP29 EP5 BP2005

  3. Packing specification: 5kg per barrel, medical aluminum bottles, lined with two layers of plastic bags, carton packaging.

  To learn more about heparin sodium, consult the heparin sodium manufacturer Kowloon Pharmaceutical For details.