The biggest side effect of chondroitin sulfate is gastrointestinal distress. It is mainly because chondroitin sulfate contains sulfate root. When it enters the human gastrointestinal tract, it will be digested through the digestive juice of the gastrointestinal tract, causing obvious stimulation to the upper digestive tract, which may result in stomachache, gastric acid, gastric distension, and even nausea and vomiting. Patients with upper gastrointestinal bleeding, as well as severe peptic ulcers, may need to be treated with caution, which can easily aggravate the disease. This is the only side effect of taking chondroitin sulfate. In addition, chondroitin sulfate is still very good. It is a drug that integrates prevention, health care and treatment. In addition to the prevention and treatment of orthopedic diseases, it has a good therapeutic effect on cardiovascular and cerebrovascular diseases and various types of neuro-painful diseases.