Heparin sodium is used in the treatment of acute thromboembolic disease, disseminated intravascular coagulation (DIC). In recent years, heparin has been found to clear blood lipid. Intravenous injection or deep intramuscular injection (or subcutaneous injection), each time 5000 ~ 10000 units.

　　Sodium heparin is less toxic and the tendency to spontaneous bleeding is the main risk of heparin overdose. Oral administration is not effective and must be injected. Intramuscular injection or subcutaneous injection is more irritating, occasionally can occur allergic reaction, overdosage can even cause cardiac arrest; Occasionally I have seen alopecia and diarrhea.

　　In addition, still can cause spontaneity fracture. Use for a long time sometimes can form thrombus, may be the consequences of anticoagulant enzyme - Ⅲ depletion. Patients with bleeding tendency, severe liver and renal insufficiency, severe hypertension, hemophilia, intracranial hemorrhage, peptic ulcer, pregnant women and postpartum, visceral tumor, trauma and surgery are forbidden to use heparin sodium.

　　Heparin calcium injection is a new subcutaneous injection of heparin sodium. Due to Ca2 + ions in heparin affinity is greater than the affinity of Na + ions in the use of heparin, often in different organizations, especially in areas such as the blood vessels and capillaries cause calcium deposits, especially the large dose of subcutaneous injection, calcium chelation destruction of adjacent capillaries penetration, thus produce the phenomenon petechial hemorrhage and hematoma.

　　Calcium heparin can avoid the imbalance of electrolytes in the blood caused by the change from sodium salt to calcium salt. It not only has the anticoagulant and thrombotic function of heparin sodium, but also is stable, quick, safe and reduces petechial point and hematoma sclerosis.