1.Heparin can increase the risk of bleeding when used in combination with the following drugs: coumarin and its derivatives, aspirin and non-steroidal anti-inflammatory analgesics, dipyridamole, dextran, adrenal corticosteroids, ACTH, tissue plasminogen activators, urokinase, streptokinase, etc.

　　2. The anticoagulant effect of heparin can be promoted by using sodium bicarbonate, sodium lactate and other drugs to correct acidosis.

　　3. Heparin mixed with hyaluronidase injection can not only relieve myodynia, but also promote the absorption of heparin. However, heparin can inhibit the activity of hyaluronidase, so they should be used together temporarily, and should not be stored for a long time after drug mixing.

　　4. Heparin can interact with insulin receptors, thereby changing the binding and action of insulin.

　　5. Should not be used with alkaline drugs.