Dermal sulfate (DS) is a disaccharide polymer, which is the most widely distributed extra cell ularmatrix (ecm) glycosaminoglycan in animals. DS is a kind of glycosaminoglycan. It is a polysaccharide composed of d-glucuronic acid and n-acetylgalactose, which is formed by repeated disaccharide units connected by the bonds of -1, 4-glucoside, and sulfated on the c-4 or c-6 hydroxyl groups of n-acetylgalactose. Due to the presence of sulfuric acid group, the whole cs molecule is very electronegative, and it is easy to covalently combine with proteins to form proteoglycan, which is also an important basis for its biological function. As an important part of connective tissue, DS has a variety of pharmacological effects and physiological functions, can be used as medicine and health food, mainly for osteoarthritis (oa) and coronary atherosclerotic heart disease (coronary heart disease).