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Physiological effects of dermatin sulfate

  Basic components of organizational structure

  DS is the main component of proteoglycan in the outer layer of vascular wall.

  Physiological function

  (1) participate in cell signal transduction

  (2) regulate cell adhesion

  (3) maintenance and inhibition of cell growth: participate in nucleic acid metabolism, increase the biosynthetic of messenger RNA (mRNA) and deoxyribonucleic acid (DNA) of cells, and promote cell metabolism.

  Participate in the pathophysiological process

  (1) cardiovascular disease

  Antithrombotic effect. (1) the anticoagulant effect is moderate, the activity is low, and there is no inhibitory effect on Xa, which is 1/40 of the effect of heparin. It inhibits and inactivates thrombin in plasma, instead of inhibiting the activation of prothrombin; (2) by heparin cofactors Ⅰ antithrombotic (HC - Ⅰ) route, and LMWH (low molecular heparin) or routine liver has been called the synergy, combined application of anticoagulant effect of reinforcement; (3) inhibition of collagen-induced platelet aggregation (Pt); (4) lower limb perfusion in rats showed that DS promoted the release of tissue-type plasminogen activator (tPA) by endothelial cells.

  Protect the vessel wall and decrease the permeability of plasma albumin.

  DS can remove lipids and lipoproteins from the blood in the body, remove cholesterol from blood vessels around the heart, prevent atherosclerosis, and increase the conversion rate of lipids and fatty acids in cells.

  (2) inflammation

  (3) tumors

  (4) infection

  (5) wound repair and fibrosis