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Pharmacokinetics of dheparin sodium

  Dheparin sodium could not be absorbed by oral administration, but became effective 3min after intravenous injection, with a maximum effect time of 2 ~ 4h and a half-life of about 2h. The effect was effective 2 ~ 4h after subcutaneous injection, the maximum effect time was 3min, the peak time was 3 ~ 4h, the half-life was about 3 ~ 5h, and the bioavailability was 87%. After multiple administration, the effect could last 10 ~ 24h. Give full play to the activity of anti thrombosis in plasma treatment of anti - Ⅹ a needed concentration range between 0.1 ~ 0.6 U/ml. To prevent left ventricular thrombosis in patients with acute anterior wall myocardial infarction, the resistance of heparin sodium - Ⅹ a blood drug concentration of 0.6 ~ 1.0 U/ml; The treatment of acute venous thrombus average shape form is needed for the formation of anti - Ⅹ a blood concentrations of 0.5 U/ml. The distribution of sodium dheparin in the body is less extensive than that of unfractionated heparin, with a distribution volume (Vd) of 40 ~ 60ml/kg or 3 ~ 11L. Dheparin sodium is mainly excreted through the kidney, and the clearance rate of the kidney is 20 ~ 30ml per minute. The half-life of patients with renal insufficiency can be prolonged.