1. Heparin can be combined with the following drugs to increase the risk of bleeding: coumarin and its derivatives, aspirin and non-steroidal anti-inflammatory and analgesic drugs, dipyridamole, dextran, adrenocorticosteroids, corticotropin, tissue plasminogen activator, urokinase, streptokinase, etc.

　　2. Heparin with sodium bicarbonate, sodium lactate and other drugs to correct acidosis can promote the anticoagulant effect of heparin.

　　3. Mixed injection of heparin and hyaluronidase can not only reduce intramuscular injection pain, but also promote heparin absorption. However, heparin can inhibit the activity of hyaluronidase, so the two should be used together temporarily.

　　Heparin ACTS with insulin receptors, thereby changing the binding and action of insulin.

　　5. Cannot be combined with alkaline drugs.

　　Description: the above contents are only for introduction, drug use must be conducted under the guidance of doctors in regular hospitals.